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Description for Protein RCHY1

ring finger and CHY zinc finger domain containing 1
11 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(phosphoproteome: 1; undefined: 1)
Summary:
The protein encoded by this gene has ubiquitin-protein ligase activity. This protein binds with p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RING: Ring finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10144
    KEGG - Pathway(s):
    hsa04115; hsa04120
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Ring finger and CHY zinc finger domain containing 1 isoform 1; Ring finger and CHY zinc finger domain containing 1 isoform 2; Ring finger and CHY zinc finger domain containing 1 isoform 3; PIRH2; CHIMP; ZNF363; ARNIP; p53 induced protein, RING-H2 domain containing; Androgen receptor N terminal domain interacting protein; CH rich interacting match with PLAG1; PRO1996; Ring finger and CHY zinc finger domain containing 1
    Approved Symbol:
    RCHY1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07607 Entrez Gene ID: 25898 OMIM ID: 607680 Swissprot Accession: Q96PM5;