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Description for Protein BACE2

beta-site APP-cleaving enzyme 2
4 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.23.45
    KEGG - Orthology:
    K07747
    KEGG - Pathway(s):
    hsa05010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Beta site amyloid beta A4 precursor protein cleaving enzyme 2; Aspartyl protease 1; ASP1; Membrane associated aspartic protease 1; ASP21; Beta secretase 2; ALP56; Down syndrome region aspartic protease; DRAP; CEAP1; BAE2; AEPLC; CDA13; Memapsin-1; 56 kDa aspartic-like protease; Transmembrane aspartic proteinase Asp1; EC 3.4.23.45; Beta-site APP-cleaving enzyme 2 isoform A preproprotein; Beta-site APP-cleaving enzyme 2 isoform C preproprotein; Beta-site APP-cleaving enzyme 2 isoform B preproprotein
    Approved Symbol:
    BACE2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 05744 Entrez Gene ID: 25825 OMIM ID: 605668 Swissprot Accession: Q9Y5Z0;