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Description for Protein PRDX5

peroxiredoxin 5
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 5/0)
(microparticles: 1; platelet: 5)
Summary:
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.11.1.15
KEGG - Orthology:
K11187
KEGG - Pathway(s):
hsa04146
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Antioxidant enzyme B166; AOEB166; Prx5; Peroxisomal antioxidant enzyme; Thioredoxin peroxidase PMP20; ACR1; PRXV; PMP20; B166; SBBI10; MGC117264; PLP; PRDX6; Alu corepressor 1; TPx type VI; Liver tissue 2D page spot 71B; Peroxiredoxin 5 mitochondrial; EC 1.11.1.15; Thioredoxin reductase; Peroxiredoxin 5 precursor isoform a; Peroxiredoxin 5 precursor isoform b; Peroxiredoxin 5 precursor isoform c
Approved Symbol:
PRDX5
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Auranofin(db);
  • Benzoic Acid(db);
  • Diminazene(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05958 Entrez Gene ID: 25824 OMIM ID: 606583 Swissprot Accession: P30044; B7ZLJ4; B7ZVW3;