Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein RASGRP3

RAS guanyl releasing protein 3 (calcium and DAG-regulated)
7 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • RasGEF: Guanine nucleotide exchange factor for Ras-like small GTPases
  • RasGEFN: Guanine nucleotide exchange factor for Ras-like GTPases
  • N-terminal motif
  • EF: EF-hand, calcium binding motif
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12362
    KEGG - Pathway(s):
    hsa04010; hsa04662
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Guanine nucleotide exchange factor for Rap1; GRP3; KIAA0846; RAS guanyl releasing protein 3 (calcium and DAG regulated)
    Approved Symbol:
    RASGRP3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15213 Entrez Gene ID: 25780 OMIM ID: 609531 Swissprot Accession: Q8IV61; Q53SD7;