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Description for Protein CBY1

chibby homolog 1 (Drosophila)
4 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    C22orf2; PIGEA14; HS508I15A; Chibby; Coiled-coil protein PIGEA-14; Polycystin-2 interactor, Golgi- and endoplasmic reticulum-associated protein, 14 kDa; PKD2 interactor, golgi and endoplasmic reticulum associated 1 isoform b; PKD2 interactor, golgi and endoplasmic reticulum associated 1 isoform a; CBY; Chromosome 22 open reading frame 2; Arb1; ARPP binding protein; Cytosolic leucine rich protein
    Approved Symbol:
    CBY1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09676 Entrez Gene ID: 25776 OMIM ID: 607757 Swissprot Accession: Q9Y3M2;