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Description for Protein GAD2

glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.1.1.15
KEGG - Orthology:
K01580
KEGG - Pathway(s):
hsa00250; hsa00410; hsa00430; hsa00650; hsa01100; hsa04940
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
GAD65; 65 kDa glutamic acid decarboxylase; EC 4.1.1.15; Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Glutamate decarboxylase 2 (pancreas)
Approved Symbol:
GAD2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Glutamic Acid(db);
  • Phenelzine(db);
  • Pyridoxal Phosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11817 Entrez Gene ID: 2572 OMIM ID: 138275 Swissprot Accession: Q05329; Q5VZ30;