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Description for Protein GABRG3

gamma-aminobutyric acid (GABA) A receptor, gamma 3
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Gamma-aminobutyric acid (GABA) receptors are a family of proteins involved in the GABAergic neurotransmission of the mammalian central nervous system. GABRG3 is a member of the GABA-A receptor gene family of heteromeric pentameric ligand-gated ion channels through which GABA, the major inhibitory neurotransmitter in the mammalian brain, acts. GABA-A receptors are the site of action of a number of important pharmacologic agents including barbiturates, benzodiazepines, and ethanol (summary by Whiting et al., 1999 [PubMed 10414349]). For additional general information about the GABA-A receptor gene family, see GABRA1 (MIM 137160).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05188
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Gamma aminobutyric acid (GABA) A receptor, gamma 3; Gamma aminobutyric acid receptor gamma 3 subunit; Gamma 3 polypeptide
    Approved Symbol:
    GABRG3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adinazolam(db);
  • Alprazolam(db);
  • Bromazepam(db);
  • Chlordiazepoxide(db);
  • Cinolazepam(db);
  • Clobazam(db);
  • Clonazepam(db);
  • Clorazepate(db);
  • Clotiazepam(db);
  • Diazepam(db);
  • Estazolam(db);
  • Fludiazepam(db);
  • Flurazepam(db);
  • Halazepam(db);
  • Lorazepam(db);
  • Midazolam(db);
  • Nitrazepam(db);
  • Oxazepam(db);
  • Prazepam(db);
  • Quazepam(db);
  • Temazepam(db);
  • Triazolam(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 02579 Entrez Gene ID: 2567 OMIM ID: 600233 Swissprot Accession: Q99928;