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Description for Protein GABRB2

gamma-aminobutyric acid (GABA) A receptor, beta 2
4 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05182
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Gamma aminobutyric acid receptor beta 2 subunit; GABA A receptor, beta 2 polypeptide; MGC119386; MGC119389; Gamma-aminobutyric acid (GABA) A receptor, beta 2 isoform 1; Gamma-aminobutyric acid (GABA) A receptor, beta 2 isoform 2
    Approved Symbol:
    GABRB2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adinazolam(db);
  • Alprazolam(db);
  • Bromazepam(db);
  • Chlordiazepoxide(db);
  • Cinolazepam(db);
  • Clobazam(db);
  • Clonazepam(db);
  • Clorazepate(db);
  • Clotiazepam(db);
  • Diazepam(db);
  • Estazolam(db);
  • Ethchlorvynol(db);
  • Fludiazepam(db);
  • Flurazepam(db);
  • Fospropofol(db);
  • Ginkgo biloba(db);
  • Halazepam(db);
  • Lorazepam(db);
  • Midazolam(db);
  • Nitrazepam(db);
  • Oxazepam(db);
  • Prazepam(db);
  • Propofol(db);
  • Temazepam(db);
  • Triazolam(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 4
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 02578 Entrez Gene ID: 2561 OMIM ID: 600232 Swissprot Accession: P47870;