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Description for Protein GABRA3

gamma-aminobutyric acid (GABA) A receptor, alpha 3
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05177
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Gaba-A receptor, alpha-3 polypeptide; Gamma-aminobutyric-acid receptor alpha-3 subunit
    Approved Symbol:
    GABRA3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adinazolam(db);
  • Alprazolam(db);
  • Amobarbital(db);
  • Aprobarbital(db);
  • Barbital(db);
  • Barbituric acid derivative(db);
  • Bromazepam(db);
  • Butabarbital(db);
  • Butalbital(db);
  • Butethal(db);
  • Chlordiazepoxide(db);
  • Cinolazepam(db);
  • Clobazam(db);
  • Clonazepam(db);
  • Clorazepate(db);
  • Clotiazepam(db);
  • Diazepam(db);
  • Estazolam(db);
  • Eszopiclone(db);
  • Ethchlorvynol(db);
  • Fludiazepam(db);
  • Flumazenil(db);
  • Flunitrazepam(db);
  • Flurazepam(db);
  • Halazepam(db);
  • Heptabarbital(db);
  • Hexobarbital(db);
  • Lorazepam(db);
  • Meprobamate(db);
  • Metharbital(db);
  • Methylphenobarbital(db);
  • Midazolam(db);
  • Nitrazepam(db);
  • Oxazepam(db);
  • Pentobarbital(db);
  • Phenobarbital(db);
  • Prazepam(db);
  • Primidone(db);
  • Quazepam(db);
  • Secobarbital(db);
  • Talbutal(db);
  • Temazepam(db);
  • Thiopental(db);
  • Triazolam(db);
  • Zolpidem(db);
  • Zopiclone(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 02375 Entrez Gene ID: 2556 OMIM ID: 305660 Swissprot Accession: P34903;