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Description for Protein GABPA

GA binding protein transcription factor, alpha subunit 60kDa
9 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SAM_PNT: SAM / Pointed domain
  • ETS: erythroblast transformation specific domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09441
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    NFT2; NRF2; NRF2A; E4TF1A; E4TF1 60; Human nuclear respiratory factor 2 subunit alpha; GA binding protein transcription factor alpha subunit 60kD; Adenovirus E4 gene transcription factor 60 kD subunit; GABP alpha subunit; Transcription factor E4TF1 60
    Approved Symbol:
    GABPA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11793 Entrez Gene ID: 2551 OMIM ID: 600609 Swissprot Accession: Q06546; Q8IYS3; A8IE48;