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Description for Protein XRCC6

X-ray repair complementing defective repair in Chinese hamster cells 6
83 total interacting proteins; 36 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • Ku78: Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen
  • VWA: von Willebrand factor (vWF) type A domain
  • SAP: Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10884
    KEGG - Pathway(s):
    hsa03450
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    G22P1; Ku70; Lupus autoantigen p70; Thyroid lupus autoantigen; TLAA; CTCBF; CTC75
    Approved Symbol:
    XRCC6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 20
    Human (de-) phosphorylation sites: 20; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01071 Entrez Gene ID: 2547 OMIM ID: 152690 Swissprot Accession: P12956; B1AHC8;