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Description for Protein G6PC

glucose-6-phosphatase, catalytic subunit
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.9
    KEGG - Orthology:
    K01084
    KEGG - Pathway(s):
    hsa00010; hsa00052; hsa00500; hsa01100; hsa04910; hsa04920
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    G6PT; G6Pase; G-6-Pase; GSD1a; Glucose-6-phosphatase, catalytic
    Approved Symbol:
    G6PC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Glycogen storage disease IA(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 9
    • Additional Identifiers:

    HPRD: 01983 Entrez Gene ID: 2538 OMIM ID: 232200 Swissprot Accession: P35575;