Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein FYN

FYN oncogene related to SRC, FGR, YES
170 total interacting proteins; 95 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/2)
(ATP binding: 1; membrane: 2; phosphoproteome: 1; platelet: 3; undefined: 1)
Summary:
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
  • Tyr_Kinase: tyrosine kinase domain
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.2
    KEGG - Orthology:
    K05703
    KEGG - Pathway(s):
    hsa04360; hsa04510; hsa04520; hsa04650; hsa04660; hsa04664; hsa05020; hsa05130; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    src-like kinase; c-syn protooncogene; Tyrosine kinase p59fyn(T); src/yes-related novel gene; OKT3-induced calcium influx regulator; proto-oncogene tyrosine-protein kinase fyn; LK; SYN; MGC45350; Protein-tyrosine kinase fyn isoform a; Protein-tyrosine kinase fyn isoform b; Protein-tyrosine kinase fyn isoform c; FYN oncogene related to SRC, FGR, YES
    Approved Symbol:
    FYN
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 32
    Human (de-) phosphorylation sites: 32; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 59
    Human phosphorylation targets: 59; Predicted platelet targets: 1
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane(db);
  • Dasatinib(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00655 Entrez Gene ID: 2534 OMIM ID: 137025 Swissprot Accession: P06241;