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Description for Protein DARC

Duffy blood group, chemokine receptor
8 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06574
    KEGG - Pathway(s):
    hsa05144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Blood group duffy system; Duffy antigen; Duffy antigen receptor for chemokines; DARC; Glycoprotein D; GpFy; Fy glycoprotein
    Approved Symbol:
    DARC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Duffy A/duffy B polymorphism(Pd);
  • Duffy null;
  • FY (A-B-)(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 7
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00192 Entrez Gene ID: 2532 OMIM ID: 110700 Swissprot Accession: Q7Z3T3; Q5Y7A2; Q16570;