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Description for Protein FUT8

fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(membrane: 2; platelet: 7; secretome: 2; undefined: 1)
Summary:
This enzyme belongs to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • CC: Coiled Coil
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.4.1.68
    KEGG - Orthology:
    K00717
    KEGG - Pathway(s):
    hsa00510; hsa00533; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Alpha 1,6 fucosyltransferase; GDP fucose glycoprotein fucosyltransferase; MGC26465; Alpha1-6FucT; Fucosyltransferase 8; Glycoprotein 6-alpha-L-fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; EC 2.4.1.68; Fucosyltransferase 8 isoform a; Fucosyltransferase 8 isoform b; Fucosyltransferase 8 isoform c
    Approved Symbol:
    FUT8
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 03994 Entrez Gene ID: 2530 OMIM ID: 602589 Swissprot Accession: Q9BYC5; Q546E0; Q8IUA5;