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Description for Protein ABL1

c-abl oncogene 1, non-receptor tyrosine kinase
133 total interacting proteins; 73 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
  • Tyr_Kinase: tyrosine kinase domain
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.2
    KEGG - Orthology:
    K06619
    KEGG - Pathway(s):
    hsa04012; hsa04110; hsa04360; hsa04722; hsa05130; hsa05131; hsa05200; hsa05220; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Proto oncogene tyrosine protein kinase ABL1; JTK7; p150; V-abl abelson murine leukemia viral oncogene homolog 1 isoform b; ABL; c-ABL; v-abl; Abelson murine leukemia viral (v-abl) oncogene homolog 1; bcr/abl; bcr/c-abl oncogene protein; EC 2.7.10.2; V-abl Abelson murine leukemia viral oncogene homolog 1 isoform a
    Approved Symbol:
    ABL1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 100
    Human (de-) phosphorylation sites: 100; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 59
    Human phosphorylation targets: 57; Predicted platelet targets: 2
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA(db);
  • 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide(db);
  • 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE(db);
  • 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE(db);
  • 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE(db);
  • Adenosine triphosphate(db);
  • Dasatinib(db);
  • Imatinib(db);
  • MYRISTIC ACID(db);
  • N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide(db);
  • Nilotinib(db)

    Associated Genetic Diseases:

  • Chronic myeloid leukemia, resistant to imatinib(Pd);
  • Leukemia, Philadelphia chromosome-positive, resistant to imatinib(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01809 Entrez Gene ID: 25 OMIM ID: 189980 Swissprot Accession: Q59FK4; P00519;