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Description for Protein FSHR

follicle stimulating hormone receptor
17 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LRR: Leucine-rich repeats, outliers
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04247
    KEGG - Pathway(s):
    hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    FSH receptor; FSH R; Follitropin receptor FSHR; LGR1; ODG1; FSHRO; Follicle stimulating hormone receptor isoform 2; Follicle stimulating hormone receptor isoform 1 precursor
    Approved Symbol:
    FSHR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Choriogonadotropin alfa(db);
  • Follitropin beta(db);
  • Menotropins(db);
  • Suramin(db);
  • Urofollitropin(db)

    Associated Genetic Diseases:

  • Ovarian dysgenesis 1(Pd);
  • Ovarian hyperstimulation syndrome(Pd);
  • Ovarian response to FSH stimulation(Pd);
  • Ovarian sex cord tumors(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 7
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 00639 Entrez Gene ID: 2492 OMIM ID: 136435 Swissprot Accession: P23945;