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Description for Protein MTOR

mechanistic target of rapamycin (serine/threonine kinase)
39 total interacting proteins; 24 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PI3KC: Phosphoinositide 3-kinase, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07203
    KEGG - Pathway(s):
    hsa04012; hsa04150; hsa04910; hsa04920; hsa04930; hsa05200; hsa05214; hsa05215; hsa05221
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    FK506 binding protein 12 rapamycin complex associated protein 1; FRAP; FRAP2; FKBP12 rapamycin complex associated protein 1; Mammalian target of rapamycin; RAFT1
    Approved Symbol:
    MTOR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 31
    Human (de-) phosphorylation sites: 31; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 10
    Human phosphorylation targets: 10; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Everolimus(db);
  • Pimecrolimus(db);
  • Sirolimus(db);
  • Temsirolimus(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03134 Entrez Gene ID: 2475 OMIM ID: 601231 Swissprot Accession: Q4LE76; P42345;