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Description for Protein ALOX12B

arachidonate 12-lipoxygenase, 12R type
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • LH2: Lipoxygenase homology 2 (beta barrel) domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.13.11.-
    KEGG - Orthology:
    K08021
    KEGG - Pathway(s):
    hsa00590; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Arachidonate 12-lipoxygenase, R type; 12-lipoxygenase, R type
    Approved Symbol:
    ALOX12B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Ichthyosiform erythroderma, congenital, nonbullous, 1(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04772 Entrez Gene ID: 242 OMIM ID: 603741 Swissprot Accession: O75342;