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Description for Protein PRPF6

PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
19 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • HAT: HAT (Half-A-TPR) repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12855
    KEGG - Pathway(s):
    hsa03040
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TOM; ANT-1; Chromosome 20 open reading frame 14; U5 snRNP associated 102 kDa protein; Androgen receptor N terminal domain transactivating protein 1; Putative mitochondrial outer membrane protein import receptor; Pre-mRNA splicing factors Prp1/Zer and Prp6; p102 U5 small nuclear ribonucleoprotein particle binding protein; C20orf14; hPrp6; U5-102K; PRP6 pre-mRNA processing factor 6 homolog; bB152O15.1; Pre-mRNA-processing factor 6
    Approved Symbol:
    PRPF6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10729 Entrez Gene ID: 24148 OMIM ID: - Swissprot Accession: O94906;