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Description for Protein ALOX5

arachidonate 5-lipoxygenase
10 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • LH2: Lipoxygenase homology 2 (beta barrel) domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.13.11.34
    KEGG - Orthology:
    K00461
    KEGG - Pathway(s):
    hsa00590; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    5 lipoxygenase; LOG5; 5-LO
    Approved Symbol:
    ALOX5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Aminosalicylic Acid(db);
  • Balsalazide(db);
  • Diethylcarbamazine(db);
  • Heme(db);
  • Hyperforin(db);
  • Leflunomide(db);
  • Masoprocol(db);
  • Meclofenamic acid(db);
  • Mesalazine(db);
  • Minocycline(db);
  • Montelukast(db);
  • Sulfasalazine(db);
  • Vitamin E(db);
  • Zileuton(db)

    Associated Genetic Diseases:

  • Asthma, diminished response to antileukotriene treatment in(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01065 Entrez Gene ID: 240 OMIM ID: 152390 Swissprot Accession: P09917;