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Description for Protein PPIL2

peptidylprolyl isomerase (cyclophilin)-like 2
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • UBOX: Modified RING finger domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    5.2.1.8
    KEGG - Orthology:
    K10598
    KEGG - Pathway(s):
    hsa04120
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    EC 5.2.1.8; Peptidylprolyl isomerase (cyclophilin) like 2; Cyclophilin like protein CyP 60; Peptidylprolyl cis trans isomerase; PPlase; Rotamase; CYP60; CYC4; MGC787; MGC33174; Peptidyl prolyl isomerase like 2; Cyclophilin 60KD; Peptidylprolyl isomerase-like 2 isoform a; Peptidylprolyl isomerase-like 2 isoform b
    Approved Symbol:
    PPIL2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08472 Entrez Gene ID: 23759 OMIM ID: 607588 Swissprot Accession: Q13356;