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Description for Protein PRKD3

protein kinase D3
8 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • PH: Pleckstrin homology domain.
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.13
    KEGG - Orthology:
    K06070
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    PKC, nu; PKC-NU; nPKC-nu; Protein kinase EPK2; PRKCN
    Approved Symbol:
    PRKD3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 35
    Human (de-) phosphorylation sites: 35; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 3
    Human phosphorylation targets: 3; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06151 Entrez Gene ID: 23683 OMIM ID: 607077 Swissprot Accession: O94806; Q53TR7;