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Description for Protein SGK3

serum/glucocorticoid regulated kinase family, member 3
5 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PX: PhoX homologous domain, present in p47phox and p40phox.
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K13304
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    CISK; SGK2; Cytokine independent survival kinase; Serum/glucocorticoid regulated kinase like; Serine/threonine-protein kinase Sgk3; SGKL; EC 2.7.1.37; Serum/glucocorticoid regulated kinase 3 isoform 2
    Approved Symbol:
    SGK3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06349 Entrez Gene ID: 23678 OMIM ID: 607591 Swissprot Accession: Q96BR1; Q5H9Q5; A6NEJ5;