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Description for Protein CBLC

Cas-Br-M (murine) ecotropic retroviral transforming sequence c
14 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999 [PubMed 10362357]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
  • RING: Ring finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K04707
    KEGG - Pathway(s):
    hsa04012; hsa04120; hsa04144; hsa04630; hsa04660; hsa04910; hsa05100; hsa05200; hsa05220
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CAS-BR-M ectopic retroviral transforming sequence C; CBL3; CBL-SL; RNF57; Signal transduction protein CBL-C; SH3-binding protein CBL-C
    Approved Symbol:
    CBLC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09765 Entrez Gene ID: 23624 OMIM ID: 608453 Swissprot Accession: Q9ULV8;