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Description for Protein BACE1

beta-site APP-cleaving enzyme 1
19 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.23.46
    KEGG - Orthology:
    K04521
    KEGG - Pathway(s):
    hsa05010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ASP2; HSPC104; KIAA1149; Memapsin 2; Beta secretase; App beta secretase; Aspartyl protease 2; Beta site App cleaving enzyme 1; Transmembrane aspartic proteinase Asp2; Membrane associated aspartic protease 2; Beta site amyloid precursor protein cleaving enzyme; EC 3.4.23.46; Beta site APP-cleaving enzyme 1 isoform A preproprotein; Beta site APP-cleaving enzyme 1 isoform C preproprotein; Beta site APP-cleaving enzyme 1 isoform B preproprotein; Beta site APP-cleaving enzyme 1 isoform D preproprotein
    Approved Symbol:
    BACE1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-ol(db);
  • (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide(db);
  • (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide(db);
  • (6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one(db);
  • (6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one(db);
  • 2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one(db);
  • 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE(db);
  • 4-(2-aminoethyl)-2-cyclohexylphenol(db);
  • 4-(2-aminoethyl)-2-ethylphenol(db);
  • 4-(4-FLUOROBENZYL)PIPERIDINE(db);
  • 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine(db);
  • 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE(db);
  • 6-[2-(3'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE(db);
  • MMI-175(db);
  • N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide(db);
  • N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE(db);
  • N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide(db);
  • N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide(db);
  • N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide(db);
  • N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide(db);
  • N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide(db);
  • N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE(db);
  • N~3~-BENZYLPYRIDINE-2,3-DIAMINE(db);
  • N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE(db);
  • N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE(db);
  • N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 07255 Entrez Gene ID: 23621 OMIM ID: 604252 Swissprot Accession: P56817;