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Description for Protein PATZ1

POZ (BTB) and AT hook containing zinc finger 1
5 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BTB: Broad-Complex, Tramtrack and Bric a brac
  • AT_hook: DNA binding domain with preference for A/T rich regions
  • ZNFC2: zinc finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    POZ at HOOK and zinc finger containing protein; PATZ; MAZ related factor; MAZR; Zinc finger sarcoma gene; ZSG; ZNF278/EWS fusion gene; Zinc finger protein 278 long A isoform; Zinc finger protein 278 long B isoform; Zinc finger protein 278 short isoform; RIAZ; ZBTB19; BTB POZ domain zinc finger transcription factor; POZ AT hook zinc finger protein; Protein kinase A RI alpha subunit associated protein; Zinc finger and BTB domain containing protein 19; Zinc finger protein 278 long C isoform
    Approved Symbol:
    PATZ1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05522 Entrez Gene ID: 23598 OMIM ID: 605165 Swissprot Accession: Q9HBE1;