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Description for Protein DDX58

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
10 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • DEXDc: DEAD-like helicases superfamily
  • HELIC: helicase superfamily c-terminal domain

  • Gene Ontology:
    Gene Ontology Annotations

    KEGG - Enzyme ID(s):
    3.6.1.-
    KEGG - Orthology:
    K12646
    KEGG - Pathway(s):
    hsa04622; hsa04623
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide RIG-I; RIG-I; FLJ13599; DKFZp434J1111; DEAD box polypeptide 58
    Approved Symbol:
    DDX58
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites

    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available


    Associated Genetic Diseases:

    None Available
    Predicted Transmembrane Domains:
  • Isoform 1 : 0
  • Additional Identifiers:

    HPRD: 13131 Entrez Gene ID: 23586 OMIM ID: 609631 Swissprot Accession: O95786