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Description for Protein ATP6V0A2

ATPase, H+ transporting, lysosomal V0 subunit a2
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.3.14
    KEGG - Orthology:
    K02154
    KEGG - Pathway(s):
    hsa00190; hsa01100; hsa04142; hsa04966; hsa05110; hsa05120
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    a2; TJ6; J6B7; Stv1; TJ6M; TJ6s; Vph1; ATP6a2; ATP6N1D; V-ATPase 116-kDa isoform a2; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2
    Approved Symbol:
    ATP6V0A2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 16521 Entrez Gene ID: 23545 OMIM ID: 611716 Swissprot Accession: Q9Y487;