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Description for Protein NNT

nicotinamide nucleotide transhydrogenase
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/0)
(membrane: 1; microparticles: 1; platelet: 9)
Summary:
This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.6.1.2
    KEGG - Orthology:
    K00324
    K00325
    KEGG - Pathway(s):
    hsa00760; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NAD(P) transhydrogenase, mitochondrial; Pyridine nucleotide transhydrogenase; MGC126502; EC 1.6.1.2; MGC126503
    Approved Symbol:
    NNT
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2'-Monophosphoadenosine 5'-Diphosphoribose(db);
  • NADH(db);
  • Tatp(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
    09715_2(12)
    09715_1(12)
    Additional Identifiers:

    HPRD: 09715 Entrez Gene ID: 23530 OMIM ID: 607878 Swissprot Accession: Q13423;