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Description for Protein POFUT1

protein O-fucosyltransferase 1
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.4.1.221
    KEGG - Orthology:
    K03691
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    OFUT1; OFUCT1; O FucT 1; GDP fucose protein O fucosyltransferase 1; KIAA0180; EC 2.4.1.221; Protein O-fucosyltransferase 1 isoform 1 precursor; Protein O-fucosyltransferase 1 isoform 2 precursor; Protein O-fucosyltransferase 1; O-fucosyltransferase protein
    Approved Symbol:
    POFUT1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06319 Entrez Gene ID: 23509 OMIM ID: 607491 Swissprot Accession: Q9H488;