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Description for Protein MACF1

microtubule-actin crosslinking factor 1
16 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PLEC: Plectin repeat
  • CC: Coiled Coil
  • SPECTRIN: Spectrin repeat
  • EF: EF-hand, calcium binding motif
  • CH: Calponin homology domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Microfilament and actin filament cross-linker protein isoform b; Microfilament and actin filament cross-linker protein isoform a; Microtubule actin crosslinking factor 1; KIAA0465; ACF7; ABP620; KIAA1251; MACF; Macrophin actin crosslinking protein superfamily member 7; Trabeculin alpha; Actin cross linking family protein 7; 620 kDa actin binding protein; MACF1-4; OFC4
    Approved Symbol:
    MACF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 83
    Human (de-) phosphorylation sites: 83; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09750 Entrez Gene ID: 23499 OMIM ID: 608271 Swissprot Accession: Q9UPN3; Q96PK2; B1ALC5;