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Description for Protein HEY2

hairy/enhancer-of-split related with YRPW motif 2
11 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ORANGE: Orange domain
  • HLH: helix loop helix domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09091
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Hairy/enhancer of split related with YRPW motif 2; HES related repressor protein 1; Gridlock; Cardiovascular basic loop helix factor; Cardiovascular basic helix loop helix protein; Hairy related transcription factor 2; HERP1; GRL
    Approved Symbol:
    HEY2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05243 Entrez Gene ID: 23493 OMIM ID: 604674 Swissprot Accession: Q9UBP5;