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Description for Protein ISCU

iron-sulfur cluster scaffold homolog (E. coli)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
None Available
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
ISCU; NIFU; ISU2; MGC74517; 2310020H20Rik; Iron-sulfur cluster assembly enzyme; Nitrogen fixation cluster-like; NifU-like N-terminal domain containing protein, mitochondrial; NifU-like protein; Iron-sulfur cluster assembly enzyme ISCU; Iron-sulfur cluster assembly enzyme isoform ISCU2 precursor; Iron-sulfur cluster assembly enzyme isoform ISCU1
Approved Symbol:
ISCU
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 11
Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 14828 Entrez Gene ID: 23479 OMIM ID: 611911 Swissprot Accession: Q9H1K1;