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Description for Protein ICMT

isoprenylcysteine carboxyl methyltransferase
4 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.1.1.100
    KEGG - Orthology:
    K00587
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Prenylcysteine carboxyl methyltransferase; Prenylated protein carboxyl methyltransferase; Protein-S isoprenylcysteine O-methyltransferase; PCMT; PPMT; PCCMT; HSTE14; MGC39955; MST098; EC 2.1.1.100; Isoprenylcysteine carboxyl methyltransferase isoform 1
    Approved Symbol:
    ICMT
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 09321 Entrez Gene ID: 23463 OMIM ID: 605851 Swissprot Accession: O60725; Q6FHT0;