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Description for Protein SIRT1

sirtuin 1
39 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.5.1.-
KEGG - Orthology:
K11411
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
SIR2L1; Sir2alpha; Sir2 like 1; Sirtuin type 1; Sirtuin (silent mating type information regulation 2, homolog) 1; OTTHUMP00000060745; RP11-57G10.3
Approved Symbol:
SIRT1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 33
Human (de-) phosphorylation sites: 33; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 08381 Entrez Gene ID: 23411 OMIM ID: 604479 Swissprot Accession: Q96EB6; A8K128;