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Description for Protein SIRT3

sirtuin 3
3 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.5.1.-
    KEGG - Orthology:
    K11413
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    SIR2 like protein 3; SIR2L3; NAD dependent deacetylase sirtuin 3 mitochondrial; Mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase; Sir2-like 3; Sirtuin 3 isoform a; Sirtuin 3 isoform b; Sirtuin (silent mating type information regulation 2 homolog) 3; hSIRT3
    Approved Symbol:
    SIRT3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine-5-Diphosphoribose(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06836 Entrez Gene ID: 23410 OMIM ID: 604481 Swissprot Accession: B7Z5U6; Q9NTG7;