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Description for Protein SIRT5

sirtuin 5
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.5.1.-
KEGG - Orthology:
K11415
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
SIR2L5; SIR2 like protein 5; EC 3.5.1.-; Sirtuin type 5; Sir2-like 5; Sirtuin 5 isoform 1; Sirtuin 5 isoform 2
Approved Symbol:
SIRT5
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2'-O-Acetyl Adenosine-5-Diphosphoribose(db);
  • Adenosine-5-Diphosphoribose(db);
  • Nicotinamide(db);
  • Nicotinamide-Adenine-Dinucleotide(db);
  • Nonaethylene Glycol(db);
  • Suramin(db);
  • Tetraethylene Glycol(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06838 Entrez Gene ID: 23408 OMIM ID: 604483 Swissprot Accession: Q9NXA8;