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Description for Protein PIP5K1C

phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
9 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
This locus encodes a type I phosphatidylinositol 4-phosphate 5-kinase. The encoded protein catalyzes phosphorylation of phosphatidylinositol 4-phosphate, producing phosphatidylinositol 4,5-bisphosphate. This enzyme is found at synapses and has been found to play roles in endocytosis and cell migration. Mutations at this locus have been associated with lethal congenital contractural syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. (PubMed Links)
Domains and Motifs:
  • PIPKc: Phosphatidylinositol phosphate kinases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.68
    KEGG - Orthology:
    K00889
    KEGG - Pathway(s):
    hsa00562; hsa01100; hsa04070; hsa04144; hsa04510; hsa04666; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PIP5K1 gamma; LCCS3; KIAA0589; PIP5K-GAMMA; Type I PIP kinase; PtdIns(4)P-5-kinase; Diphosphoinositide kinase; Phosphatidylinositol-4-phosphate 5-kinase I-gamma; EC 2.7.1.68; PtdInsPKIgamma
    Approved Symbol:
    PIP5K1C
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05834 Entrez Gene ID: 23396 OMIM ID: 606102 Swissprot Accession: O60331;