Summary:
Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq] (PubMed Links)
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| Domains and Motifs:
Gene Ontology:
KEGG - Enzyme ID(s):
KEGG - Orthology:
K05955
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KEGG - Pathway(s):
None Available
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Nomenclature / Alternative Names:
Type I protein geranyl-geranyltransferase alpha subunit; FPTA; PGGT1A; Hypothetical protein MGC99680; GGTase-I-alpha; Farnesyltransferase, CAAX box, alpha isoform b; Farnesyltransferase, CAAX box, alpha isoform c; CAAX farnesyltransferase alpha subunit; Ras proteins prenyltransferase alpha; FTase alpha; Farnesyltransferase CAAX box alpha; EC 2.5.1.58; EC 2.5.1.59
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Approved Symbol:
| (De-) Phosphorylations:
Phosphorylation Targets:
| Total phosphorylation targets: 0 |
| Human phosphorylation targets: 0; | Predicted platelet targets: 0 |
| Protein Characteristics:
|  Associated Drugs (DrugBank Accession):
(11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE(db);
(20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE(db);
(20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE(db);
2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE(db);
2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE(db);
4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE(db);
ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID(db);
FARNESYL(db);
FARNESYL DIPHOSPHATE(db);
GERANYLGERANYL DIPHOSPHATE(db);
[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID(db)
Associated Genetic Diseases:
None Available
| Predicted Transmembrane Domains:
Isoform 3 : 0
Isoform 2 : 0
Isoform 1 : 0
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