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Description for Protein ARHGEF12

Rho guanine nucleotide exchange factor (GEF) 12
12 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/2)
(phosphoproteome: 1; platelet: 1; undefined: 1)
Summary:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PH: Pleckstrin homology domain.
  • CC: Coiled Coil
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
  • RHOGEF: Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07532
    KEGG - Pathway(s):
    hsa04270; hsa04360; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    KIAA0382; LARG; LARG/MLL fusion gene; Leukemia associated RhoGEF; Leukemia associated rho guanine nucleotide exchange factor
    Approved Symbol:
    ARHGEF12
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09207 Entrez Gene ID: 23365 OMIM ID: 604763 Swissprot Accession: Q9NZN5;