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Description for Protein UBR4

ubiquitin protein ligase E3 component n-recognin 4
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(membrane: 1; platelet: 6; secretome: 1)
Summary:
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.3.2.19
KEGG - Orthology:
K10691
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
KIAA0462; KIAA1307
Approved Symbol:
UBR4
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 35
Human (de-) phosphorylation sites: 35; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10184 Entrez Gene ID: 23352 OMIM ID: 609890 Swissprot Accession: Q5T4S7;