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Description for Protein FN1

fibronectin 1
81 total interacting proteins; 34 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/0)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 3; secretome: 9)
Summary:
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • FN3: Fibronectin type 3 domain
  • FN1: Fibronectin type 1 domain
  • FN2: Fibronectin type 2 domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05717
    KEGG - Pathway(s):
    hsa04510; hsa04512; hsa04810; hsa05100; hsa05200; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    FN; LETS; Cold insoluble globulin; CIG; MSF; FINC; Migration stimulating factor; Large external transformation sensitive protein; DKFZp686H0342; DKFZp686I1370; DKFZp686F10164; DKFZp686O13149
    Approved Symbol:
    FN1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 32
    Human (de-) phosphorylation sites: 32; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00626 Entrez Gene ID: 2335 OMIM ID: 135600 Swissprot Accession: Q6MZM7; P02751; Q6N084;