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Description for Protein FBXW11

F-box and WD repeat domain containing 11
34 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • F_BOX: A Receptor for Ubiquitination Targets
  • WD40: WD40 repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03362
    KEGG - Pathway(s):
    hsa04114; hsa04120; hsa04310; hsa04340; hsa05131
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Hos; Fbw11; F-box and WD-40 domain protein 1B isoform C; F-box and WD-40 domain protein 1B isoform B; F-box and WD-40 domain protein 1B isoform A; FBW1B; Beta transducin repeat containing protein 2; F box and WD40 domain protein 1B; BTRCP2; KIAA0696; BTRC2; FBXW1B; F box and WD 40 domain protein 11; F box protein Fbw1b; F box/WD repeat protein 1B; F box and WD repeats protein beta TrCP2
    Approved Symbol:
    FBXW11
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07294 Entrez Gene ID: 23291 OMIM ID: 605651 Swissprot Accession: Q9UKB1;