Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein FLT4

fms-related tyrosine kinase 4
13 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • IG: Immunoglobulin
  • IGC2: Immunoglobulin C-2 Type
  • TM: Transmembrane domain
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K05097
    KEGG - Pathway(s):
    hsa04060; hsa04510
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    FMS related tyrosine kinase 4; VEGFR3; Vascular endothelial growth factor receptor 3; EC 2.7.1.112; Tyrosine protein kinase receptor FLT4; PCL; FMS related tyrosine kinase 4 isoform 2; FMS related tyrosine kinase 4 isoform 1
    Approved Symbol:
    FLT4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Sorafenib(db);
  • Sunitinib(db)

    Associated Genetic Diseases:

  • Hemangioma, capillary infantile, somatic(Pd);
  • Lymphedema, hereditary, I(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00636 Entrez Gene ID: 2324 OMIM ID: 136352 Swissprot Accession: P35916; Q86W07; Q86W08;