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Description for Protein PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)
13 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • PLCXc: Phospholipase C, catalytic domain (part)
  • domain X
  • PLCYc: Phospholipase C, catalytic domain (part)
  • domain Y
  • C2: Protein kinase C conserved region 2 (CalB)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.11
    KEGG - Orthology:
    K05858
    KEGG - Pathway(s):
    hsa00562; hsa01100; hsa04020; hsa04062; hsa04070; hsa04270; hsa04310; hsa04540; hsa04720; hsa04730; hsa04912; hsa04916; hsa04970; hsa05010; hsa05016; hsa05142
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PLC, beta 1; 1 phosphatidylinositol 4,5 bisphosphate phosphodiesterase beta 1; PLC beta 1; PLC 1; PLC 154; Phospholipase C, beta 1 (phosphoinositide specific); Phosphoinositide specific phospholipase C beta 1; PI-PLC; Phosphoinositidase C; Inositoltrisphosphohydrolase; Triphosphoinositide phosphodiesterase; Monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; EC 3.1.4.11; Phosphoinositide phospholipase C; KIAA0581; Phosphoinositide-specific phospholipase C beta 1 isoform a; Posphoinositide-specific phospholipase C beta 1 isoform b
    Approved Symbol:
    PLCB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06177 Entrez Gene ID: 23236 OMIM ID: 607120 Swissprot Accession: Q9NQ66;