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Description for Protein FLT3

fms-related tyrosine kinase 3
14 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • IG: Immunoglobulin
  • TM: Transmembrane domain
  • Tyr_Kinase: tyrosine kinase domain
  • Ig_LIKE: Immunoglobulin like
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K05092
    KEGG - Pathway(s):
    hsa04060; hsa04640; hsa05200; hsa05221
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Stem cell tyrosine kinase 1; STK1; FLK2; CD135 antigen; EC 2.7.10.1
    Approved Symbol:
    FLT3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 17
    Human (de-) phosphorylation sites: 17; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 2
    Human phosphorylation targets: 2; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Sorafenib(db);
  • Sunitinib(db)

    Associated Genetic Diseases:

  • Leukemia, acute lymphoblastic(Pd);
  • Leukemia, acute myeloid(Pd);
  • Leukemia, acute myeloid, reduced survival in(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 00635 Entrez Gene ID: 2322 OMIM ID: 136351 Swissprot Accession: P36888;