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Description for Protein FLT1

fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
24 total interacting proteins; 19 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/2)
(platelet: 1; undefined: 1)
Summary:
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • Ig_LIKE: Immunoglobulin like
  • IGC2: Immunoglobulin C-2 Type
  • TM: Transmembrane domain
  • Tyr_Kinase: tyrosine kinase domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K05096
    KEGG - Pathway(s):
    hsa04060; hsa04144; hsa04510
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    FLT; Vascular endothelial growth factor receptor 1; VEGFR1; FMS related tyrosine kinase 1
    Approved Symbol:
    FLT1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide(db);
  • Sunitinib(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01297 Entrez Gene ID: 2321 OMIM ID: 165070 Swissprot Accession: B5A923; P17948; B3FR89;