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Description for Protein FLNC

filamin C, gamma
29 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/1)
(alpha granules: 1; membrane: 1; microparticles: 1; phosphoproteome: 1; platelet: 2; undefined: 1)
Summary:
This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CH: Calponin homology domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04437
    KEGG - Pathway(s):
    hsa04010; hsa04510
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Filamin gamma; ABPL; Filamin 2; FLN2; ABP280A; ABPA; Actin binding protein 280
    Approved Symbol:
    FLNC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Filaminopathy, autosomal dominant(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00018 Entrez Gene ID: 2318 OMIM ID: 102565 Swissprot Accession: Q14315; Q59H94;