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Description for Protein MAPK8IP3

mitogen-activated protein kinase 8 interacting protein 3
24 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04436
    KEGG - Pathway(s):
    hsa04010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    JIP3; SYD2; JSAP1; FLJ00027; KIAA1066; JNK MAP kinase scaffold protein 3; C jun amino terminal kinase interacting protein 3; JNK/Stress activated protein kinase associated protein 1; Mitogen-activated protein kinase 8 interacting protein 3 isoform 1; JNK/SAPK-associated protein-1; JNK-interacting protein 3; Mitogen-activated protein kinase 8 interacting protein 3 isoform 2; DKFZp762N1113; Sunday driver 2
    Approved Symbol:
    MAPK8IP3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 22
    Human (de-) phosphorylation sites: 22; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 12014 Entrez Gene ID: 23162 OMIM ID: 605431 Swissprot Accession: Q9UPT6;